NCIt definition : A humanized immunoglobulin G1 (IgG1) antibody directed against the human T-cell-expressed
receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon intravenous administration,
anti-CTLA-4 monoclonal antibody ADU-1604 targets and binds to CTLA-4 expressed on
T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This
leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells.
CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF),
plays a key role in the downregulation of the immune system.;