NCIt definition : A human monoclonal antibody with a masked antibody binding site directed against the
human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4;
CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon intravenous administration and the activation of the antibody binding site in
the tumor microenvironment (TME), muzastotug targets and binds to CTLA-4 expressed
on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This
leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells,
thereby killing cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin
superfamily (IgSF), plays a key role in the downregulation of the immune system.;
UNII : 4L1XJF3HGL;
CAS number : 2750031-18-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2750031-18-4
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G-SRS /a ;
Semantic type(s)