NCIt definition : A human monoclonal antibody with a masked antibody binding site directed against the
human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4;
CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon intravenous administration and the activation of the antibody binding site in
the tumor microenvironment (TME), muzastotug targets and binds to CTLA-4 expressed
on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This
leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells,
thereby killing cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin
superfamily (IgSF), plays a key role in the downregulation of the immune system.;
Semantic type(s)