NCIt definition : A fully humanized, Fc-engineered monoclonal antibody with masked antigen-binding regions
directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated
antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic
activities. Upon administration and the activation of the antigen-binding regions
via cleavage by proteases that are upregulated in the tumor microenvironment (TME),
vilastobart targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated
downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated
immune response against cancer cells, thereby killing cancer cells. CTLA-4, an inhibitory
receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in
the downregulation of the immune system.;
Semantic type(s)