NCIt definition : A recombinant, humanized immunoglobulin (Ig) G1 monoclonal antibody directed against
the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4;
CTLA-4; CD152), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration, futermestotug targets and binds to CTLA-4 expressed on T-cells
and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to
a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells, thereby
killing cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin
superfamily (IgSF), plays a key role in the downregulation of the immune system.;
Semantic type(s)