" /> Futermestotug - CISMeF





Preferred Label : Futermestotug;

NCIt synonyms : Anti-CTLA-4 Monoclonal Antibody YH001;

NCIt definition : A recombinant, humanized immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4; CD152), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, futermestotug targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells, thereby killing cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system.;

UNII : LSX3UPC7JY;

CAS number : 3014361-57-7;

Molecule name : YH 001; YH-001;

NCI Metathesaurus CUI : CL1642930;

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31/07/2025


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