Interleukin-23

Preferred Label : Interleukin-23;

NCIt synonyms : Interleukin 23; IL23; IL-23;

NCIt definition : A heterodimeric cytokine composed of interleukin-12 subunit beta and interleukin-23 subunit alpha. This complex binds to the interleukin-23 receptor complex, which activates the JAK-STAT signaling pathway and modulates the proliferation, differentiation and effector functions of T-lymphocytes, natural killer cells and some myeloid lineage cells.;

NCI Metathesaurus CUI : CL546020;

Details

Origin ID

C147535;

UMLS CUI

C0963088;

Automatic exact mappings (from CISMeF team)
- Interleukin 23 [LOINC component]
- Interleukin-23 [MeSH concept]
- Interleukin-23 [MeSH Descriptor]
- interleukin-23 receptor binding [GO term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Interleukin 23 [LOINC component]
- Interleukin-23 [MeSH Descriptor]
- Interleukin-23 [MeSH concept]
gene_product_has_biochemical_function
- Interleukin [NCIt concept]
gene_product_plays_role_in_biological_process
- Antimicrobial Effect [NCIt concept]
- NK Cell Activation [NCIt concept]
- T-Cell Activation [NCIt concept]
has_gene_product_element
- Interleukin-12 Subunit Beta [NCIt concept]
- Interleukin-23 Subunit Alpha [NCIt concept]

Keyword's position in hierarchy(ies) :

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