IL12A wt Allele

Preferred Label : IL12A wt Allele;

NCIt synonyms : CLMF; IL-12A; NKSF1; Interleukin 12A (Natural Killer Cell Stimulatory Factor 1, Cytotoxic Lymphocyte Maturation Factor 1, P35) wt Allele; NFSK; P35;

NCIt definition : Human IL12A wild-type allele is located within 3p12-q13.2 and is approximately 7 kb in length. This allele, which encodes interleukin-12 alpha chain protein, is involved in promoting the growth of both T cells and natural killer cells. It also plays a role in the differentiation of both Th1 and Th2 cells.;

NCIt note : Certain polymorphisms in the IL12A gene may affect the final steps in gastric carcinogenesis in patients with H. pylori infection.;

GenBank Accession Number : NM_000882;

Details

Origin ID

C52042;

UMLS CUI

C1704794;

OMIM relation
- Interleukin 12a [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 3: 161189331-161196508 [NCIt concept]
gene_in_chromosomal_location
- 3p12-q13.2 [NCIt concept]
gene_is_element_in_pathway
- Allograft Rejection Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Cytokine Network Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Dendritic Cell Pathway [NCIt concept]
- IL12 Signaling Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- IL18 Signaling Pathway [NCIt concept]
- IL27-Mediated Signaling Pathway [NCIt concept]
- Inflammatory Response Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- NO2-Dependent IL12 Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- T-Cell Polarization Pathway [NCIt concept]
- Th1/Th2 Differentiation Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- Type I Diabetes Mellitus Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cell-Mediated Immunity [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- NK Cell Activation [NCIt concept]
- T-Cell Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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