Heme Oxygenase 1

Preferred Label : Heme Oxygenase 1;

NCIt synonyms : HO-1; HMOX1; HO1; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; EC 1.14.14.18;

NCIt definition : Heme oxygenase 1 (288 aa, 33 kDa) is encoded by the human HMOX1 gene. This protein is involved in heme metabolism.;

NCIt note : Heme oxygenase 1 cleaves the alpha methene bridge of the heme ring to form biliverdin (converted to bilirubin by biliverdin reductase) and carbon monoxide. (UniProt);

Details

Origin ID

C43318;

UMLS CUI

C1565861;

Currated CISMeF NLP mapping
- Heme oxygenase (decyclizing) (substance) [SNOMED CT concept]
- heme Oxygenase-1 [MeSH concept]
- heme oxygenase (decyclizing) [SNOMED Notion]
- heme oxygenase-1 [MeSH Descriptor]
OMIM relation
- Heme oxygenase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HMOX1 protein, human [MeSH Supplementary Concept]
- HMOX1 protein, human [MeSH concept]
- heme Oxygenase-1 [MeSH concept]
- heme oxygenase-1 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HMOX1 Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- IL10 Anti-inflammatory Signaling Pathway [NCIt concept]
- Oxidative Stress Pathway [NCIt concept]
- Porphyrin and Chlorophyll Metabolism Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Squamous Cell Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Catabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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