NADPH-Cytochrome P450 Reductase

Preferred Label : NADPH-Cytochrome P450 Reductase;

NCIt synonyms : POR; NADPH-Specific Cytochrome C Reductase; EC 1.6.2.4; Cytochrome-P450 Reductase; Cytochrome P450 Reductase; CPR; P450R; NADPH--Cytochrome P450 Reductase;

NCIt definition : NADPH-cytochrome P450 reductase (677 aa, 77 kDa) is encoded by the human POR gene. This protein plays a role in electron transfer.;

NCIt note : NADPH-cytochrome P450 reductase (POR; CPR) forms an electron-transfer complex with Aromatase (CYP19A1) during the aromatization reaction. (J Steroid Biochem Mol Biol. 2010; 118: 203-206. doi: 10.1016/j.jsbmb.2009.11.010);

Details

Origin ID

C16890;

UMLS CUI

C4078840;

Automatic exact mappings (from CISMeF team)
- ACACB protein, human [MeSH Supplementary Concept]
- Acetyl-CoA carboxylase [MeSH Descriptor]
- Adh5 protein, mouse [MeSH Supplementary Concept]
- BCCP2 protein, arabidopsis [MeSH Supplementary Concept]
- CARD11 protein, human [MeSH Supplementary Concept]
- CPRR1 protein, cotton [MeSH Supplementary Concept]
- CPRR2 protein, cotton [MeSH Supplementary Concept]
- Cytochrome p450 oxidoreductase [OMIM gene]
- GC-G protein, mouse [MeSH Supplementary Concept]
- GCY-18 protein, C elegans [MeSH Supplementary Concept]
- GCY-23 protein, C elegans [MeSH Supplementary Concept]
- GCY-35 protein, C elegans [MeSH Supplementary Concept]
- GCY-36 protein, C elegans [MeSH Supplementary Concept]
- GCY-8 protein, C elegans [MeSH Supplementary Concept]
- GCY-9 protein, C elegans [MeSH Supplementary Concept]
- GUCY2F protein, human [MeSH Supplementary Concept]
- Gucy2d protein, mouse [MeSH Supplementary Concept]
- Gucy2d protein, rat [MeSH Supplementary Concept]
- Gucy2e protein, mouse [MeSH Supplementary Concept]
- Gucy2e protein, rat [MeSH Supplementary Concept]
- Gucy2f protein, mouse [MeSH Supplementary Concept]
- Gucy2f protein, rat [MeSH Supplementary Concept]
- Gyc76C protein, Drosophila [MeSH Supplementary Concept]
- HFA1 protein, S cerevisiae [MeSH Supplementary Concept]
- NADPH-Ferrihemoprotein reductase [MeSH concept]
- NADPH-Ferrihemoprotein reductase [MeSH Descriptor]
- NADPH-hemoprotein reductase activity [GO term]
- Vari protein, Drosophila [MeSH Supplementary Concept]
- acacb protein, mouse [MeSH Supplementary Concept]
- accA protein, E coli [MeSH Supplementary Concept]
- accC protein, E coli [MeSH Supplementary Concept]
- accD protein, E coli [MeSH Supplementary Concept]
- atrial natriuretic factor receptor A [MeSH Supplementary Concept]
- atrial natriuretic factor receptor B [MeSH Supplementary Concept]
- atrial natriuretic factor receptor C [MeSH Supplementary Concept]
- biotin carboxyl carrier protein [MeSH Supplementary Concept]
- cardiopulmonary resuscitation [MeSH Descriptor]
- cpr [MedlinePlus Topic]
- cytochrome p450 oxidoreductase [ORDO Gene]
- flavocytochrome P450 BM3 monoxygenases [MeSH Supplementary Concept]
- galactonate dehydratase [MeSH Supplementary Concept]
- glycine transaminase [MeSH Descriptor]
- guanylate cyclase [MeSH Descriptor]
- guanylyl cyclase-G, mouse [MeSH Supplementary Concept]
- porcupine O-acyltransferase [ORDO Gene]
- portraits as topic [MeSH Descriptor]
- receptors, atrial natriuretic factor [MeSH Descriptor]
- receptors, guanylate cyclase-coupled [MeSH Descriptor]
- resact protein, sea urchin [MeSH Supplementary Concept]
OMIM relation
- Cytochrome p450 oxidoreductase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- POR protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
- POR Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Oxidative Stress Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Estrogen Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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