AP-1 Complex - CISMeF

Preferred Label : AP-1 Complex;

NCIt synonyms : Enhancer-Binding Protein AP1; AP1; AP-1; Activator Protein 1 Complex; Transcription Factor AP-1 Complex; Activator Protein 1;

NCIt definition : A dimeric complex of related bZIP JUN, FOS, MAF and ATF transcription factors that must dimerize in order to bind to AP1 recognition sites (TPA-Responsive Element, TRE) or cAMP response elements in DNA, AP-1 controls basal and inducible transcription of several genes.;

Details

Origin ID

C17450;

UMLS CUI

C3271456;

Currated CISMeF NLP mapping
- transcription factor AP-1 [MeSH concept]
- transcription factor ap-1 [MeSH Descriptor]
False automatic mappings
- autoimmune polyendocrinopathy syndrome, type 1 [MeSH Supplementary Concept]
OMIM relation
- Jun protooncogene, ap-1 transcription factor subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Transcription Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- bZIP Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcriptional Regulation [NCIt concept]
has_gene_product_element
- FOS Family Protein [NCIt concept]
- Fos-Related Antigen 1 [NCIt concept]
- JUN Family Protein [NCIt concept]
- MAF Family Protein [NCIt concept]
- Protein FosB [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transcription Factor Jun-B [NCIt concept]
- Transcription Factor Jun-D [NCIt concept]

Keyword's position in hierarchy(ies) :

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