FOS Family Protein

Preferred Label : FOS Family Protein;

NCIt synonyms : FOS Protein;

NCIt definition : The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. (LocusLink);

Details

Origin ID

C18090;

UMLS CUI

C0596588;

Automatic exact mappings (from CISMeF team)
- Proto-Oncogene proteins c-fos [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- FOS Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- bZIP Domain [NCIt concept]
gene_product_is_physical_part_of
- AP-1 Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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