IL6 Signaling Pathway

Preferred Label : IL6 Signaling Pathway;

NCIt related terms : IL 6 signaling pathway;

Alternative definition : BIOCARTA: Interleukin-6 (IL-6) is a cytokine that provokes a broad range of cellular and physiological responses. In addition to playing a role in inflammation and hematopoiesis, IL-6 is involved in other processes such as neuronal differentiation and bone loss. To produce these effects IL-6 signals through a receptor composed of two different subunits, an alpha subunit that produces ligand specificity and gp130, a receptor subunit shared in common with other cytokines in the IL-6 family. Binding of IL-6 to its receptor initiates cellular events including activation of JAK kinases and activation of ras-mediated signaling. Activated JAK kinases phosphorylate and activate STAT transcription factors, particularly STAT3, that move into the nucleus to activate transcription of genes containing STAT3 response elements. The ras-mediated pathway, acting through Shc, Grb-2 and Sos-1 upstream and activating Map kinases downstream, activates transcription factors such as ELK-1 and NF-IL-6 (C/EBP-beta) that can act through their own cognate response elements in the genome. These factors and other transcription factors like AP-1 and SRF (serum response factor) that respond to many different signaling pathways come together to regulate a variety of complex promoters and enhancers that respond to IL-6 and other signaling factors. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_il6Pathway;

Details

Origin ID

C39127;

UMLS CUI

C1512598;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Casein Kinase II Subunit Alpha [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- GTPase HRas [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Interleukin-6 [NCIt concept]
- Interleukin-6 Receptor Subunit Alpha [NCIt concept]
- Interleukin-6 Receptor Subunit Beta [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Signal Transducer and Activator of Transcription 3 [NCIt concept]
- Soluble Interleukin-6 Receptor Subunit Alpha [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Tyrosine-Protein Kinase JAK3 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 11 [NCIt concept]
pathway_has_gene_element
- CSNK2A1 wt Allele [NCIt concept]
- ELK1 wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IL6 wt Allele [NCIt concept]
- IL6R wt Allele [NCIt concept]
- IL6ST wt Allele [NCIt concept]
- JAK3 wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- PTPN11 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- STAT3 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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