Interleukin-6 Receptor Subunit Beta

Preferred Label : Interleukin-6 Receptor Subunit Beta;

NCIt synonyms : Oncostatin M Receptor; CD130 Antigen; Interleukin Receptor Beta Chain; Membrane Glycoprotein gp130; gp130 Transducer Chain; IL6ST; CDw130; IL-6R-Beta; CD130; Oncostatin-M Receptor Subunit Alpha; gp130; IL-6 Receptor Subunit Beta; Interleukin-6 Signal Transducer; Membrane Glycoprotein 130; IL-6RB; Interleukin 6 Signal Transducer; IL-6R Subunit Beta;

NCIt definition : Interleukin-6 receptor subunit beta (918 aa, 104 kDa) is encoded by the human IL6ST gene. This protein is involved in cytokine receptor-mediated signal transduction.;

NCIt note : Interleukin-6 receptor subunit beta contains 5 fibronectin type III domains, an Ig-like C2-type domain, a BOX 1 motif required for JAK interaction/activation, and a WSXWS motif necessary for protein folding, intracellular transport, and cell-surface receptor binding.; Homodimers of interleukin-6 receptor subunit beta bind to two molecules of human herpesvirus-8 (Kaposi Sarcoma Herpes Virus) viral interleukin-6 homolog protein. (UniProt);

Details

Origin ID

C26265;

UMLS CUI

C1366325;

Automatic exact mappings (from CISMeF team)
- 2-phenyl-5,5-dimethyltetrahydro-1,4-oxazine [MeSH Supplementary Concept]
- Interleukin 6 cytokine family signal transducer [OMIM gene]
- Oncostatin M receptor [OMIM gene]
- ciliary neurotrophic factor receptor activity [GO term]
- cytokine receptor gp130 [MeSH concept]
- cytokine receptor gp130 [MeSH Descriptor]
- interleukin-11 receptor activity [GO term]
- interleukin-6 receptor activity [GO term]
- leucine rich pentatricopeptide repeat containing [ORDO Gene]
- obsolete gp130 [GO term]
- oncostatin M receptor [HGNC gene]
- oncostatin M receptor [ORDO Gene]
OMIM relation
- Interleukin 6 cytokine family signal transducer [OMIM gene]
See also inter- (CISMeF)
- interleukin 6 cytokine family signal transducer [HGNC gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
UMLS correspondences (same concept)
- IL6ST protein, human [MeSH concept]
- IL6ST protein, human [MeSH Supplementary Concept]
Validated automatic mappings to NTBT
- receptors, oncostatin M [MeSH concept]
- receptors, oncostatin m [MeSH Descriptor]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- IL6ST Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- ERBB2 Signaling Pathway [NCIt concept]
- IL27-Mediated Signaling Pathway [NCIt concept]
- IL6 Signaling Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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