" /> Interleukin-3 Receptor Subunit Alpha - CISMeF





Preferred Label : Interleukin-3 Receptor Subunit Alpha;

NCIt synonyms : IL3R; IL3R-Alpha; IL3RA; Interleukin 3 Receptor Alpha Chain; IL3RX; CD123; Low Affinity Interleukin 3 Receptor Alpha; CD123 Antigen; Interleukin 3 Receptor; IL-3R Subunit Alpha; Interleukin 3 Receptor Alpha; IL-3 Receptor Subunit Alpha; IL-3R-Alpha; IL-3RA; Interleukin-3 Receptor Alpha;

NCIt definition : Interleukin-3 receptor subunit alpha (378 aa, 43 kDa) is encoded by the human IL3RA gene. This protein is involved in interleukin-3 signaling.;

NCIt note : Interleukin-3 receptor subunit alpha is a type I membrane protein with a box 1 motif for JAK interaction/activation; a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. It is also the ligand-binding alpha subunit of the heterodimeric cytokine receptor for interleukin-3 (IL3). Receptor binding to IL3 depends on the cytokine receptor common subunit beta, which is shared by IL3-, IL5-, and CSF2/GM-CSF receptors.;

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30/04/2024


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