" /> Autologous Anti-CD123 CAR-T Cells - CISMeF





Preferred Label : Autologous Anti-CD123 CAR-T Cells;

NCIt synonyms : Autologous Anti-CD123 Chimeric Antigen Receptor T Cells; CD123 CAR-T Cells; Autologous Anti-CD123 CAR T Cells;

NCIt definition : A preparation of autologous T-cells engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD123 (interleukin-3 receptor alpha chain or IL3RA), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD123 CAR-T cells target and bind to CD123 expressed on the surface of tumor cells. This induces selective toxicity in CD123-expressing tumor cells. CD123, the alpha subunit of the IL-3 receptor, regulates the proliferation, survival and differentiation of hematopoietic cells. It is overexpressed on a variety of cancers, including myeloid leukemia, and the increased expression of CD123 on leukemic stem cells (LSCs) is associated with poor prognosis.;

NCI Metathesaurus CUI : CL1405393;

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12/05/2024


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