Preferred Label : CD123-CD33 Compound CAR T Cells;
NCIt synonyms : CD123-CD33 cCAR T-cells; 123b-33bcCAR T-cells; CD123/CD33-expressing Compound CAR-T Cells; CD123-CD33 cCAR T Cells;
NCIt definition : A preparation of T-lymphocytes transduced with a lentiviral vector expressing a compound
chimeric antigen receptor (cCAR) containing two distinct units of CARs, one specific
for the CD123 (interleukin-3 receptor alpha chain or IL3RA) antigen and one specific
for the CD33 antigen, with potential immunomodulating and antineoplastic activities.
Upon administration, the CD123-CD33 cCAR T cells specifically and simultaneously target
and bind to tumor cells expressing CD123 and/or CD33. This induces selective toxicity
in tumor cells that express the CD123 antigen and/or the CD33 antigen. CD123 is normally
expressed on committed blood progenitor cells in the bone marrow; its overexpression
is associated with increased leukemic cell proliferation and aggressiveness. CD33
is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed
on myeloid leukemia cells. Targeting two different antigens may improve coverage and
protect against antigen escape and relapse as it is less likely for tumor cells to
lose both antigens. Additionally, the CD123-CD33 cCAR T cells express CD52 on the
cell surface. This allows the depletion of the CD123-CD33 cCAR T cells with the administration
of the anti-CD52 monoclonal antibody alemtuzumab, in case of unacceptable side effects.;
NCI Metathesaurus CUI : CL1407854;
Origin ID : C173970;
UMLS CUI : C5420490;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
