NCIt definition : A fully human monoclonal antibody against CD123 (interleukin-3 receptor alpha chain)
with potential antineoplastic activity. Anti-CD123 monoclonal antibody KHK2823 binds
to and neutralizes CD123, which is upregulated on leukemic stem cells (LSC) found
in myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). This agent may
inhibit IL-3-dependent signaling and proliferation and may prevent the uncontrolled
growth and differentiation of mutated LSC.;