" /> Autologous Anti-CD123 CAR TCR/4-1BB-expressing T-lymphocytes - CISMeF





Preferred Label : Autologous Anti-CD123 CAR TCR/4-1BB-expressing T-lymphocytes;

NCIt synonyms : Anti-CD123 CAR mRNA-electroporated Autologous T-lymphocytes; Autologous Anti-CD123 CAR TCR/4-1BB-expressing T Lymphocytes; RNA Anti-CD123 CAR T Cells; Autologous RNA CART123 Cells; RNA CART123 Cells;

NCIt definition : Autologous, genetically engineered T-lymphocytes that have been electroporated with a messenger RNA (mRNA) encoding a chimeric antigen receptor (CAR) consisting of an anti-human interleukin-3 receptor alpha chain (IL3RA; CD123) single chain variable fragment (scFv) coupled to the co-stimulatory signaling domains of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCR) CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, the mRNA-electroporated autologous anti-CD123 CAR TCR/4-1BB expressing T-lymphocytes attach to cancer cells expressing CD123. This induces selective toxicity in and causes lysis of CD123-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances T-cell activation and signaling after recognition of CD123. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness.;

NCI Metathesaurus CUI : CL503939;

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10/05/2024


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