NCIt synonyms : Bispecific Anti-CD123 x Anti-CD3 Antibody APVO436; Anti-CD123 x Anti-CD3 Bispecific Antibody APVO436; CD123 x CD3 Targeting Bispecific Antibody APVO436; Anti-CD123/CD3 Bispecific Antibody APVO436;
NCIt definition : An immunoglobulin Fc-modified bispecific monoclonal antibody against the tumor-associated
antigen (TAA) CD123 and the human T-cell surface antigen CD3 bispecific monoclonal
antibody, with potential immunostimulatory and antineoplastic activities. Upon administration,
mipletamig simultaneously binds to both CD3-expressing T-cells and CD123-expressing
cancer cells, thereby crosslinking CD123-expressing tumor cells and cytotoxic T-lymphocytes
(CTLs). This results in the activation and proliferation of T-cells and causes CTL-mediated
cell lysis of CD123-expressing tumor cells. CD123, the interleukin-3 receptor alpha
chain, is overexpressed in a variety of hematological malignancies; its expression
is low or absent in normal hematopoietic progenitors and stem cells. The Fc domain
on the antibody prolongs the half-life of the bispecific antibody. Compared to some
other CD123 x CD3 targeting bispecific antibodies, mipletamig causes less cytokine
release upon T-cell stimulation.;
Semantic type(s)