NCIt synonyms : Bispecific Anti-CD123 x Anti-CD3 Antibody APVO436; Anti-CD123 x Anti-CD3 Bispecific Antibody APVO436; CD123 x CD3 Targeting Bispecific Antibody APVO436;
NCIt related terms : APVO-436;
NCIt definition : An immunoglobulin Fc-modified bispecific monoclonal antibody against the tumor-associated
antigen (TAA) CD123 and the human T-cell surface antigen CD3 bispecific monoclonal
antibody, with potential immunostimulatory and antineoplastic activities. Upon administration,
anti-CD123/CD3 monoclonal antibody APVO436 simultaneously binds to both CD3-expressing
T-cells and CD123-expressing cancer cells, thereby crosslinking CD123-expressing tumor
cells and cytotoxic T-lymphocytes (CTLs). This results in the activation and proliferation
of T-cells and causes CTL-mediated cell lysis of CD123-expressing tumor cells. CD123,
the interleukin-3 receptor alpha chain, is overexpressed in a variety of hematological
malignancies; its expression is low or absent in normal hematopoietic progenitors
and stem cells. The Fc domain on the antibody prolongs the half-life of the bispecific
antibody. Compared to some other CD123 x CD3 targeting bispecific antibodies, APVO436
causes less cytokine release upon T-cell stimulation.;
Semantic type(s)