Preferred Label : CD123-specific Targeting Module TM123;
NCIt synonyms : CD123-specific TM TM123; CD123 Target Module TM123; Recombinant Antibody Derivative TM123;
NCIt definition : A preparation of soluble adapter molecules consisting of an antigen-binding moiety
targeting CD123 linked to a peptide motif recognizable by UniCAR02-T, that may be
used to activate UniCAR02-T. Upon administration of CD123-specific targeting module
(TM) TM123, and upon co-administration of UniCAR02-T, the antigen-binding moiety of
TM123 targets and binds to cancer cells expressing CD123, and the binding domain of
UniCAR02-T binds to the nuclear antigen motif of TM123. This activates UniCAR02-T,
and induces selective toxicity in and causes lysis of CD123-expressing tumor cells.
CD123 is normally expressed on committed blood progenitor cells in the bone marrow;
its overexpression is associated with both increased leukemic cell proliferation and
aggressiveness.;
Molecule name : TM 123; TM-123;
NCI Metathesaurus CUI : CL1412859;
Origin ID : C175461;
UMLS CUI : C5446542;
Semantic type(s)
- concept_is_in_subset
- has_target
