Preferred Label : Pivekimab Sunirine;
NCIt synonyms : Antibody-drug Conjugate IMGN632; CD123-targeted ADC IMGN632; Anti-CD123 ADC IMGN632;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a humanized anti-CD123 (interleukin-3
(IL-3) receptor alpha chain; IL3RA) immunoglobulin G1 (IgG1) monoclonal antibody conjugated,
via a cleavable linker, to a cytotoxic, DNA-alkylating payload, which is an indolino-benzodiazepine
dimer containing an imine moiety, with potential antineoplastic activity. Upon administration
of anti-CD123 ADC IMGN632, the antibody moiety targets the cell surface antigen CD123.
Upon antibody/antigen binding, internalization, and lysosome uptake, the cytotoxic
moiety is released, and covalently binds to and alkylates DNA with its imine moiety.
This results in cell cycle arrest in S-phase, which leads to apoptosis and inhibition
of cell growth in cells overexpressing CD123. CD123, the alpha subunit of the IL-3
receptor, regulates the proliferation, survival and differentiation of hematopoietic
cells. CD123 is overexpressed on a variety of cancers.;
UNII : L15LO3W1XX;
CAS number : 2417174-95-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2417174-95-7
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G-SRS /a ;
Molecule name : IMGN-632; IMGN 632;
NCI Metathesaurus CUI : CL541645;
Origin ID : C184834;
UMLS CUI : C5669572;
Semantic type(s)
- concept_is_in_subset
- has_target
