Preferred Label : Allogeneic Anti-CD123 CAR-NK Cells JD123;
NCIt synonyms : Allogeneic CD123-targeted CAR NK Cells JD123;
NCIt definition : A preparation of off-the-shelf (OTS), allogeneic natural killer (NK) cells engineered
to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen
(TAA) human interleukin-3 receptor alpha chain (IL3RA; cluster of differentiation
123; CD123), with potential immunomodulating and antineoplastic activities. Upon administration,
allogeneic anti-CD123 CAR-NK cells JD123 recognize, bind to and induce selective cytotoxicity
in CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor
cells in the bone marrow; its overexpression is associated with both increased leukemic
cell proliferation and aggressiveness.;
Molecule name : JD 123; JD-123;
NCI Metathesaurus CUI : CL1928611;
Origin ID : C206269;
concept_is_in_subset
- has_target
