Preferred Label : NKp46/CD16-based CD123-targeted NK Cell Engager SAR443579;
NCIt synonyms : NKp46/CD16-based NKCE IPH6101; NKCE SAR443579;
NCIt definition : An engineered tri-specific natural killer (NK) cell engager (NKCE) containing specific
antibodies targeting the tumor-associated antigen cluster of differentiation 123 (CD123),
and the NK activating receptors natural cytotoxicity triggering receptor (NKp46; activating
natural killer receptor p46) and CD16, with potential immunostimulating and antineoplastic
activities. Upon administration of NKp46/CD16-based CD123-targeted NK cell engager
SAR443579, the NKCE targets and binds to CD123 expressed on tumor cells and simultaneously
binds, via the activating receptors NKp46 and CD16, to NK cells, thereby bringing
CD123-expressing tumor cells and NK cells together. This stimulates the NK cells and
results in the selective NK cell-mediated tumor cell lysis of CD123-expressing tumor
cells. CD123 is normally expressed on committed blood progenitor cells in the bone
marrow; its overexpression is associated with both increased leukemic cell proliferation
and aggressiveness.;
Molecule name : SAR 443579; IPH-6101; SAR-443579; IPH 6101;
NCI Metathesaurus CUI : CL1773834;
Origin ID : C185407;
UMLS CUI : C5666986;
Semantic type(s)
- concept_is_in_subset
- has_target
