Preferred Label : Anti-CD123-Pyrrolobenzodiazepine Dimer Antibody Drug Conjugate SGN-CD123A;
NCIt synonyms : Anti-CD123-PBD ADC SGN-CD123A; Anti-CD123 ADC SGN-CD123A; Antibody-drug Conjugate SGN-CD123A; ADC SGN-CD123A;
NCIt related terms : SGN-CD123A;
NCIt definition : An antibody-drug conjugate (ADC) consisting of an anti-CD123 humanized monoclonal
antibody conjugated, via a stable maleimidocaproyl-valine-alanine dipeptide protease-cleavable
linker, to the cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine
(PBD) dimer, with potential antineoplastic activity. Upon administration of anti-CD123
ADC SGN-CD123A, the antibody moiety targets the cell surface antigen CD123. Upon antibody/antigen
binding, internalization, and lysosome uptake, the cytotoxic PBD moiety is released.
In turn, the imine groups of the PBD moiety bind to the N2 positions of guanines on
opposite strands of DNA. This induces DNA strand breaks, inhibits DNA replication,
leads to G2/M cell cycle arrest, induces cell death, and inhibits the proliferation
of CD123-overexpressing tumor cells. CD123, the alpha subunit of the IL-3 receptor,
regulates the proliferation, survival and differentiation of hematopoietic cells.
CD123 is overexpressed on a variety of cancers, including myeloid leukemia, and increased
expression of CD123 on leukemic stem cells is associated with poor prognosis. Cysteine
engineering of the monoclonal antibody (EC-mAb) allows for a site-specific, stable
conjugation and uniform loading of the PBD agent to the antibody.;
UNII : 89ATB9I3D2;
Molecule name : SGN CD123A; SGN-CD123A;
NCI Metathesaurus CUI : CL512667;
Origin ID : C129457;
UMLS CUI : C4329311;
Semantic type(s)
- concept_is_in_subset
- has_target
