NCIt definition : An Fc-bearing, bispecific antibody-like protein directed against the tumor-associated
antigen (TAA) CD123 and the human T-cell surface antigen CD3, with potential immunostimulatory
and antineoplastic activities. Upon administration, anti-CD123/anti-CD3 bispecific
DART molecule MGD024 simultaneously binds to both CD123-expressing cancer cells and
CD3-expressing T-cells, thereby crosslinking CD123-expressing tumor cells and cytotoxic
T-lymphocytes (CTLs). This results in the activation and proliferation of T-cells
and causes CTL-mediated cell lysis of CD123-expressing tumor cells. CD123, the interleukin-3
receptor alpha chain, is overexpressed in a variety of hematological malignancies;
its expression is low or absent in normal hematopoietic progenitors and stem cells.
The Fc domain prolongs the half-life of the agent, and a reduced affinity of CD3-binding
results in less cytokine release.;
Semantic type(s)