Preferred Label : Anti-CD123/CD16A Bispecific Antibody AFM28;
NCIt synonyms : Bispecific Innate Cell Engager AFM28; Bispecific Antibody Anti-CD123/Anti-CD16A AFM28; ICE AFM28;
NCIt definition : A human, tetravalent, bispecific immunoglobulin G1 (IgG1)-single chain variable fragment
(scFv) fusion antibody targeting both the tumor-associated antigen (TAA) CD123 and
the human low affinity immunoglobulin G (IgG) Fc region receptor IIIA (FCGR3A; CD16A),
with potential immunomodulating and antineoplastic activities. Upon administration,
anti-CD123/CD16A bispecific antibody AFM28 simultaneously targets and binds to CD16A
expressed on natural killer (NK) cells and macrophages, and to CD123 on CD123-expressing
tumor cells, thereby selectively cross-linking CD123-expressing tumor cells with NK
cells and macrophages. This may result in NK cell and macrophage activation, induce
antibody-dependent cellular cytotoxicity (ADCC), and eventually causes tumor cell
lysis. CD123 is overexpressed in a variety of hematological malignancies; its expression
is low or absent in normal hematopoietic progenitors and stem cells. CD16A is specifically
expressed on the surface of NK cells and macrophages.;
Molecule name : AFM-28; AFM 28;
NCI Metathesaurus CUI : CL1907534;
Origin ID : C200544;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
