Preferred Label : Allogeneic CD123-specific Universal CAR123-expressing T-lymphocytes;
NCIt synonyms : Universal TALEN Gene-edited CART123 Cells; Allogeneic Engineered T-cells Expressing Anti-CD123 Chimeric Antigen Receptor; UCART123; UCART123 T Cells; Universal Chimeric Antigen Receptor T-cells targeting CD123; Universal Chimeric Antigen Receptor T-cell 123;
NCIt definition : Allogeneic, off-the-shelf, universal transcription activator-like effector nuclease
(TALEN)-engineered T-lymphocytes that have been genetically modified to express a
chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human
interleukin-3 receptor alpha chain (IL3RA; cluster of differentiation 123; CD123),
with potential immunomodulating and antineoplastic activities. Upon transfusion of
allogeneic CD123-specific universal CAR123-expressing T-lymphocytes (UCART123), these
cells target and bind to cancer cells expressing CD123. This induces selective toxicity
in and causes lysis of CD123-expressing tumor cells. CD123 is normally expressed on
committed blood progenitor cells in the bone marrow; its overexpression is associated
with both increased leukemic cell proliferation and aggressiveness. Using TALEN technology,
the UCART123 cells no longer express the endogenous T-cell receptor (TCR) thereby
abrogating the potential induction of graft-versus-host disease (GvHD) by the donor
T-cells.;
NCI Metathesaurus CUI : CL544763;
Origin ID : C146806;
UMLS CUI : C4687465;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
