Preferred Label : CD123-Specific Adapter SPRX002;
NCIt synonyms : TAG Protein SPRX002; Monovalent CD123-targeting Protein SPRX002; SparX Protein Targeting CD123 SPRX002; Monovalent CD123-Specific Adapter SPRX002; Protein-targeting CD123 SPRX002;
NCIt definition : A soluble protein antigen-receptor X-linker (sparX) protein containing a CD123 tumor-associated
antigen (TAA) binding-domain and a TAG domain, which contains a fragment of human
alpha fetoprotein (AFP), with binding ability to CD123-specific tumor cells and universal
CAR-modified T-cells (antigen-receptor complex-T-cells; ARC-T-cells), respectively.
Upon administration, the CD123-specific adapter SPRX002 targets and binds, with its
anti-CD123 binding domain, to CD123-expressing tumor cells and, with its TAG region,
targets and binds to the anti-TAG binding domain on the ARC-T-cells. When ARC-T-cells
bind to the TAG domain of SPRX002 and SPRX002 is bound to CD123-expressing cancer
cells, the tricomplex formation leads to T-cell activation, expansion and killing
of CD123-expressing cancer cells. The combination of SPRX002 with ARC-T-cells is called
ACLX002. Since the dose of SPRX002 can be adjusted, it allows for the controllability
and adaptability of the ARC-T-cells and reduces its potential toxicity .CD123 is normally
expressed on committed blood progenitor cells in the bone marrow; its overexpression
is associated with both increased leukemic cell proliferation and aggressiveness.;
Molecule name : SPRX 002; SPRX-002;
NCI Metathesaurus CUI : CL1799386;
Origin ID : C190741;
UMLS CUI : C5787240;
Semantic type(s)
- concept_is_in_subset
- has_target
