Preferred Label : Allogeneic CD123CAR-CD28-CD3zeta-EGFRt-expressing T-lymphocytes;
NCIt synonyms : Allogeneic CD123R(EQ)28zeta/EGFRt T Cells;
NCIt definition : A preparation of genetically modified allogeneic T-cells transduced with a replication-incompetent,
self-inactivating lentiviral vector expressing a hinge-optimized, chimeric antigen
receptor (CAR), comprised of a CD28 co-stimulatory signaling domain fused to CD3 zeta,
the single-chain variable fragment of CD123 antigen (interleukin-3 receptor alpha
chain or IL3RA), and a truncated form of the human epidermal growth factor receptor
(EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous
administration, allogeneic CD123CAR-CD28-CD3zeta-EGFRt-expressing T-lymphocytes are
directed to and induce selective toxicity in CD123-expressing tumor cells. CD123 is
normally expressed on committed blood progenitor cells in the bone marrow; its overexpression
is associated with increased leukemic cell proliferation and aggressiveness. Devoid
of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates
detection of the administered T-cells in vivo and can promote elimination of those
cells following a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC)
response. The costimulatory signaling domain enhances both proliferation of T-cells
and antitumor activity. Hinge optimization prevents recognition of the CAR by Fc receptors
(FcRs).;
Origin ID : C125420;
UMLS CUI : C4085945;
Semantic type(s)
- concept_is_in_subset
- has_target
