Preferred Label : Anti-CD123/Duocarmazine ADC BYON4413;
NCIt synonyms : Anti-CD123 Antibody-drug Conjugate BYON4413; Anti-CD123 ADC BYON4413;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a humanized, immunoglobulin G1 (IgG1)
monoclonal antibody against the interleukin-3 (IL3)-receptor alpha chain (CD123; IL-3RA)
that is site-specifically conjugated to the cleavable linker-duocarmycin payload duocarmazine
(valine-citrulline-seco duocarmycin hydroxybenzamide azaindole; vc-seco-DUBA; SYD980),
with potential antineoplastic activity. Upon administration of anti-CD123/duocarmazine
ADC BYON4413, the antibody moiety targets and binds to the cell surface antigen CD123
expressed on tumor cells. Upon binding, internalization and cleavage of the vc linker
inside the tumor cell by proteases, duocarmycin is released and binds to the minor
groove of DNA. This alkylates adenine at the N3 position, and induces cell death specifically
in tumor cells expressing CD123. CD123 regulates the proliferation, survival and differentiation
of hematopoietic cells. CD123 is overexpressed on a variety of cancers, including
myeloid leukemia, and increased expression of CD123 on leukemic stem cells is associated
with poor prognosis.;
Molecule name : SYD 4413; BYON 4413; SYD-4413; BYON4413;
Origin ID : C215077;
concept_is_in_subset
- has_target
