Preferred Label : Anti-CD123/CD3 Bispecific Antibody JNJ-63709178;
NCIt synonyms : Humanized CD123 x CD3 DuoBody JNJ-63709178;
NCIt definition : A humanized anti-CD123/anti-CD3 bispecific monoclonal antibody, with potential immunostimulating
and antineoplastic activities. Anti-CD123/CD3 bispecific antibody JNJ-63709178 possesses
two antigen-recognition and binding sites, one for the CD3 complex, a group of T-cell
surface glycoproteins that complex with the T-cell receptor (TCR), and one for CD123,
a tumor-associated antigen (TAA) overexpressed on the surface of certain tumor cells.
Upon administration of JNJ-63709178, this bispecific antibody simultaneously binds
to both CD3-expressing T-cells and CD123-expressing cancer cells, thereby crosslinking
CD123-expressing tumor cells and cytotoxic T-lymphocytes (CTLs). This may result in
potent CTL-mediated cell lysis of CD123-expressing tumor cells. CD123, the interleukin-3
receptor alpha chain, is overexpressed in a variety of cancers; its expression is
low or absent in normal, healthy cells.;
Molecule name : JNJ-63709178;
NCI Metathesaurus CUI : CL507949;
Origin ID : C128486;
UMLS CUI : C4287748;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
