NCIt definition : A bispecific T-cell engager (BiTE) antibody comprised of a humanized Fc-silenced immunoglobulin
G1 (IgG1) backbone and two single-chain variable fragments (scFvs): one directed against
the CD3 antigen expressed on T-lymphocytes and another directed against the alpha-chain
of the interleukin-3 receptor (IL-3RA; CD123), with potential immunostimulating and
antineoplastic activities. Upon intravenous infusion, anti-CD123/CD3 BiTE antibody
SAR440234 binds to both CD3 expressed on T-cells and CD123 expressed on tumor cells.
This activates and redirects cytotoxic T-lymphocytes (CTLs) to CD123-expressing tumor
cells, leading to enhanced CTL-mediated elimination of CD123-expressing tumor cells.
CD123 is overexpressed in a variety of hematological malignancies; its expression
is low or absent in normal hematopoietic progenitors and stem cells.;
Semantic type(s)