NCIt synonyms : CD123 x CD3 Dual Affinity Re-Targeting Bi-Specific Antibody MGD006; CD123 x CD3 DART Bi-Specific Antibody MGD006;
NCIt definition : An anti-CD123/anti-CD3 bispecific humanized monoclonal antibody with potential immunostimulatory
and antineoplastic activities. Flotetuzumab possesses two antigen-recognition and
binding sites, one for the CD3 complex, a group of T-cell surface glycoproteins that
complex with the T-cell receptor (TCR), and one for CD123, a tumor-associated antigen
(TAA) overexpressed on the surface of certain tumor cells. Upon administration of
flotetuzumab, this bispecific antibody simultaneously binds to both CD3-expressing
T-cells and CD123-expressing cancer cells, thereby crosslinking CD123-expressing tumor
cells and cytotoxic T-lymphocytes (CTLs). This may result in potent CTL-mediated cell
lysis of CD123-expressing tumor cells. CD123, the interleukin-3 receptor alpha chain,
is overexpressed in a variety of hematological malignancies; its expression is low
or absent in normal hematopoietic progenitors and stem cells.;
Semantic type(s)