Fibroblast Growth Factor Receptor Substrate 3

Preferred Label : Fibroblast Growth Factor Receptor Substrate 3;

NCIt synonyms : FRS3; FRS2B; FRS2-Beta; SUC1-Associated Neurotrophic Factor Target 2; SNT2; Testicular Tissue Protein Li 71; SNT-2; FGFR Substrate-3; FGFR-Signaling Adaptor SNT2; FGFR Substrate 3;

NCIt definition : Fibroblast growth factor receptor substrate 3 (492 aa, 54 kDa) is encoded by the human FRS3 gene. This protein plays a role in linking fibroblast growth factor receptors and nerve growth factor receptors to downstream signaling factors.;

NCIt note : FRS3 contains a myristylation sequence, a PTB domain, and Tyr-containing motifs that govern GRB2 and SHP2 recruitment. FRS3 binds directly to FGFR1; an FGFR1 juxtamembrane segment and the PTB domain appear to interact and mediate FRS Tyr phosphorylation.;

Details

Origin ID

C29588;

UMLS CUI

C1333545;

OMIM relation
- Fibroblast growth factor receptor substrate 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- FRS3 protein, human [MeSH concept]
- FRS3 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- FRS3 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- PTB Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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