Preferred Label : Pleckstrin Homology Domains;
MeSH definition : Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel
beta sheets connected by a loop of variable length and a C-terminal amphipathic helix.
PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS
where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES,
as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING
PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins
to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS.;
MeSH synonym : Domain, Pleckstrin Homology; Domains, Pleckstrin Homology; Homology Domain, Pleckstrin; Homology Domains, Pleckstrin; PH Domain; Domain, PH; Domains, PH; PH Domains; Pleckstrin Homology Domain;
Wikipedia link : https://en.wikipedia.org/wiki/Pleckstrin homology domain;
Origin ID : D000070539;
UMLS CUI : C1518792;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel
beta sheets connected by a loop of variable length and a C-terminal amphipathic helix.
PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS
where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES,
as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING
PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins
to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS.
