Calcium-Dependent Secretion Activator 2

Preferred Label : Calcium-Dependent Secretion Activator 2;

NCIt synonyms : Ca -Dependent Secretion Activator 2; Ca2 -Dependent Activator Protein for Secretion 2; Ca2 Dependent Secretion Activator 2; Ca -Dependent Activator Protein for Secretion 2; CAPS-2; Calcium-Dependent Activator Protein for Secretion 2; CADPS2; Calcium Dependent Secretion Activator 2;

NCIt definition : Calcium-dependent secretion activator 2 (1296 aa, 148 kDa) is encoded by the human CADPS2 gene. This protein is involved in the secretion of neurotrophins.;

NCIt note : Variation in the calcium-dependent secretion activator 2 protein may be associated with breast cancer as a patient with chemorefractory hormone receptor (HR)-positive metastatic breast cancer had complete regression of the cancer for over 22 months after treatment with tumor-infiltrating lymphocytes (TILs) that targeted mutant forms of this and three other proteins that were expressed in the patient's tumor in conjunction with aldesleukin and pembrolizumab. (Nature Medicine 2018; 24:724-730);

NCI Metathesaurus CUI : CL937984;

Details

Origin ID

C158577;

UMLS CUI

C4761550;

Automatic exact mappings (from CISMeF team)
- Calcium-dependent activator protein for secretion 2 [OMIM gene]
- Calcyphosine 2 [OMIM gene]
- Muckle-wells syndrome [OMIM Phenotype]
- calcium dependent secretion activator 2 [HGNC gene]
OMIM relation
- Calcium-dependent activator protein for secretion 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
gene_encodes_gene_product
- CADPS2 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Cellular Vesicle [NCIt concept]
- Outer Leaflet of the Lipid Bilayer [NCIt concept]
gene_product_has_chemical_classification
- Calcium Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- C2 Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- PH Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Exocytosis [NCIt concept]
- Ligand Binding [NCIt concept]
- Phospholipid Binding [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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