Tyrosine-Protein Kinase BTK

Preferred Label : Tyrosine-Protein Kinase BTK;

NCIt synonyms : B-Cell Progenitor Kinase; BPK; ATK; Bruton Tyrosine Kinase; Agammaglobulinaemia Tyrosine Kinase; BTK;

NCIt definition : Tyrosine-protein kinase BTK (659 aa, 76 kDa) is encoded by the human BTK gene. This protein is involved in both B-cell development and signal transduction.;

Details

Origin ID

C75017;

UMLS CUI

C1528376;

Currated CISMeF NLP mapping
- Agammaglobulinaemia Tyrosine Kinase [MeSH Descriptor]
- agammaglobulinaemia tyrosine kinase [MeSH concept]
OMIM relation
- Bruton agammaglobulinemia tyrosine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- BTK protein, human [MeSH concept]
- BTK protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- BTK Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_gene_product_variant
- BTK C481 Resistance Mutation [NCIt concept]
- BTK NP_000052.1:p.C481S [NCIt concept]
- BTK NP_000052.1:p.C481X [NCIt concept]
- BTK Protein Variant [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- PH Domain [NCIt concept]
- SH2 Domain [NCIt concept]
- SH3 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- B-Cell Differentiation [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Acalabrutinib [NCIt concept]
- Acalabrutinib Maleate Monohydrate [NCIt concept]
- BTK Degrader [NCIt concept]
- BTK Degrader ABBV-101 [NCIt concept]
- BTK Degrader AC0676 [NCIt concept]
- BTK Degrader BGB-16673 [NCIt concept]
- BTK Degrader HSK29116 [NCIt concept]
- BTK Degrader NX-5948 [NCIt concept]
- BTK Inhibitor ABBV-992 [NCIt concept]
- BTK Inhibitor CT-1530 [NCIt concept]
- BTK Inhibitor DTRMWXHS-12 [NCIt concept]
- BTK Inhibitor GB5121 [NCIt concept]
- BTK Inhibitor HMPL-760 [NCIt concept]
- BTK Inhibitor HZ-A-018 [NCIt concept]
- BTK Inhibitor JNJ-64264681 [NCIt concept]
- BTK Inhibitor TL-895 [NCIt concept]
- BTK Inhibitor TQB3702 [NCIt concept]
- BTK Inhibitor TT-01488 [NCIt concept]
- DTRMWXHS-12/Everolimus/Pomalidomide Combination Agent DTRM-555 [NCIt concept]
- Docirbrutinib [NCIt concept]
- Edralbrutinib [NCIt concept]
- Evobrutinib [NCIt concept]
- Fenebrutinib [NCIt concept]
- Ibrutinib [NCIt concept]
- Luxeptinib [NCIt concept]
- Nemtabrutinib [NCIt concept]
- Orelabrutinib [NCIt concept]
- Pirtobrutinib [NCIt concept]
- Poseltinib [NCIt concept]
- Rilzabrutinib [NCIt concept]
- Rocbrutinib [NCIt concept]
- Spebrutinib [NCIt concept]
- Spebrutinib Besylate [NCIt concept]
- Tirabrutinib [NCIt concept]
- Tirabrutinib Hydrochloride [NCIt concept]
- Tolebrutinib [NCIt concept]
- Vecabrutinib [NCIt concept]
- Zanubrutinib [NCIt concept]
- Zebutinib [NCIt concept]
- Zelebrudomide [NCIt concept]

Keyword's position in hierarchy(ies) :

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