Rho Guanine Nucleotide Exchange Factor 7

Preferred Label : Rho Guanine Nucleotide Exchange Factor 7;

NCIt synonyms : Beta-Pix; p85; PAK-Interacting Exchange Factor Beta; COOL-1; ARHGEF7;

NCIt definition : Rho guanine nucleotide exchange factor 7 (803 aa, 90 kDa) is encoded by the human ARHGEF7 gene. This protein plays a role in both the modulation of small GTPase activity and the induction of apoptosis.;

Details

Origin ID

C97202;

UMLS CUI

C3275251;

Automatic exact mappings (from CISMeF team)
- Rho guanine nucleotide exchange factor 7 [OMIM gene]
- Rho guanine nucleotide exchange factor 7 [HGNC gene]
- phosphoinositide-3-kinase regulatory subunit 1 [ORDO Gene]
- phosphoinositide-3-kinase regulatory subunit 2 [ORDO Gene]
- rho guanine nucleotide exchange factors [MeSH Descriptor]
Currated CISMeF NLP mapping
- rho guanine nucleotide exchange factor 7 [MeSH concept]
OMIM relation
- Rho guanine nucleotide exchange factor 7 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ARHGEF7 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- ARHGEF7 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
gene_product_has_structural_domain_or_motif
- DH Domain [NCIt concept]
- PH Domain [NCIt concept]
- SH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Aurora A Signaling Pathway [NCIt concept]
- Internalization Pathway for Epidermal Growth Factor Receptor [NCIt concept]
gene_product_plays_role_in_biological_process
- Positive Regulation of Apoptosis [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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