Mitogen-Activated Protein Kinase Kinase Kinase 8

Preferred Label : Mitogen-Activated Protein Kinase Kinase Kinase 8;

NCIt synonyms : p38 MAPK; COT Gene Product; MAP-Kinase Kinase Kinase 8; MAP3K8 Kinase; Cancer Osaka Thyroid Oncogene Protein; MAP3K8; Ewing Sarcoma Transformant; C-COT; COT Proto-Oncogene Serine/Threonine-Protein Kinase; EC 2.7.11.25; MAP Kinase Kinase Kinase 8; TPL-2; Serine/Threonine-Protein Kinase Cot; Proto-Oncogene c-Cot; Tumor Progression Locus 2; Tpl2;

NCIt definition : Mitogen-activated protein kinase kinase kinase 8 (467 aa, 58 kDa) is encoded by the human MAP3K8 gene. This protein plays a role in T cell activation and serine/threonine phosphorylation.;

Details

Origin ID

C20585;

UMLS CUI

C1307220;

OMIM relation
- Mitogen-activated protein kinase kinase kinase 8 [OMIM gene]
See also inter- (CISMeF)
- Mitogen-activated protein kinase kinase kinase 8 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAP3K8 protein, human [MeSH Supplementary Concept]
- MAP3K8 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAP3K8 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- PH Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- MAPKinase Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Thyroid Gland Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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