Growth Factor Receptor-Bound Protein 10

Preferred Label : Growth Factor Receptor-Bound Protein 10;

NCIt synonyms : GRB10; Growth Factor Receptor-Bound Protein-10; Grb-10; GRB10 Adapter Protein; GRB10 Adaptor Protein; Insulin Receptor-Binding Protein Grb-IR;

NCIt definition : Growth factor receptor-bound protein 10 (594 aa, 67 kDa) is encoded by the human GRB10 gene. This protein plays a role in linking cell surface receptor kinases with their specific downstream signaling pathways.;

NCIt note : Grb10 interacts with FGFR1, INSR, IGF1R, MET, PDGFRB, and weakly with EGFR. (UniProt).;

Details

Origin ID

C26228;

UMLS CUI

C1430275;

OMIM relation
- Growth factor receptor-bound protein 10 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GRB10 protein, human [MeSH Supplementary Concept]
- GRB10 protein, human [MeSH concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- GRB10 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- PH Domain [NCIt concept]
- SH2 Domain [NCIt concept]
gene_product_is_element_in_pathway
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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