Phosphoinositide Pathway

Preferred Label : Phosphoinositide Pathway;

NCIt related terms : Phosphoinositides and their downstream targets;

Alternative definition : BIOCARTA: Nine currently identified phosphoinositide 3-kinases (PI 3-K) constitute a subfamily of lipid kinases that catalyze the addition of a phosphate molecule on the 3-position of the inositol ring of phosphoinositides. Phosphatidylinositol (PtdIns), the precursor of all phosphoinositides (PI), constitutes less than 10% of the total lipid in eukaryotic cell membranes. Approximately 5% of cellular PI is phosphorylated at the 4-position (PtdIns-4-P), and another 5% is phosphorylated at both the 4- and 5-positions (PtdIns-4, 5-P2). However, less than 0.25% of the total inositol-containing lipids are phosphorylated at the 3-position, consistent with the idea that these lipids exert specific regulatory functions inside the cell, as opposed to a structural function. Here we have chosen to highlight a group of the phosphoinositide targets of the PI3-Ks and their downstream targets. The downstream effects of these PI-3 targets are indicated, illustrating the important role the PI3Ks have in cell function and survival. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_ptdinsPathway;

Details

Origin ID

C39204;

UMLS CUI

C1519052;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- ADP-Ribosylation Factor 1 [NCIt concept]
- Bcl2 Antagonist of Cell Death [NCIt concept]
- Glycogen Synthase Kinase-3 Alpha [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Guanine Nucleotide Exchange Factor VAV2 [NCIt concept]
- Protein TAMALIN [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 2 [NCIt concept]
- Tyrosine-Protein Kinase Lyn [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- ARF1 wt Allele [NCIt concept]
- ARHGEF2 wt Allele [NCIt concept]
- BAD wt Allele [NCIt concept]
- GSK3A wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- LYN wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- TAMALIN wt Allele [NCIt concept]
- VAV2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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