GSK3A wt Allele

Preferred Label : GSK3A wt Allele;

NCIt synonyms : Glycogen Synthase Kinase 3 Alpha wt Allele; GSK3-alpha;

NCIt definition : Human GSK3A wild-type allele is located in the vicinity of 19q13.2 and is approximately 12 kb in length. This allele, which encodes glycogen synthase kinase-3 alpha protein, plays a role in the regulation of both glycogen synthesis and the Wnt/beta-catenin signaling pathway.;

NCIt note : The GSK3A gene product is necessary for production of the beta-amyloid-40 and -42 peptides generated from the amyloid precursor protein. Increased production and aggregation of these peptides into plaques is associated with the development of Alzheimer's disease.;

GenBank Accession Number : NM_019884;

Details

Origin ID

C51206;

UMLS CUI

C1706400;

Automatic exact mappings (from CISMeF team)
- glycogen synthase kinase 3 alpha [MeSH Supplementary Concept]
OMIM relation
- Glycogen synthase kinase 3-alpha [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 19q13.2 [NCIt concept]
gene_is_element_in_pathway
- Chemokine Signaling Pathway [NCIt concept]
- FOXM1 Transcription Factor Signaling Pathway [NCIt concept]
- Phosphoinositide Pathway [NCIt concept]
gene_plays_role_in_process
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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