Claudin-18 Isoform A2

Preferred Label : Claudin-18 Isoform A2;

NCIt synonyms : Claudin 18 Isoform A2; Claudin 18 Isoform 2; CLDN18.2; Claudin 18.2; Claudin-18 Isoform 2; Claudin-18.2; CLDN-18.2;

NCIt definition : Claudin-18 isoform A2 (261 aa, 28 kDa) is encoded by the human CLDN18 gene. This protein is involved in tight junction formation in the epithelium of the gastric mucosa.;

NCIt note : The transcript encoding claudin-18 isoform A2 utilizes the start codon in exon 1b (1.2).; Claudin-18 isoform A2 is specifically expressed in normal differentiated epithelial cells of the gastric mucosa. (Clin Cancer Res 2008;14:7624-7634);

NCI Metathesaurus CUI : CL552140;

Details

Origin ID

C150412;

UMLS CUI

C4725710;

OMIM relation
- Claudin 18 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CLDN18 Gene [NCIt concept]
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Epithelium [NCIt concept]
- Gastric Mucosa [NCIt concept]
gene_product_has_associated_anatomy
- Epithelial Cell [NCIt concept]
- Plasma Membrane [NCIt concept]
- Tight Junction [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
is_target
- Anti-CD3/Anti-Claudin18.2 Bispecific Antibody IBI389 [NCIt concept]
- Anti-CLDN18.2 CAR T Cells LY011 [NCIt concept]
- Anti-CLDN18.2 CAR-T Cells AZD6422 [NCIt concept]
- Anti-CLDN18.2 Heavy Chain Antibody Fc Fusion Protein DR30303 [NCIt concept]
- Anti-CLDN18.2 Monoclonal Antibody ZL-1211 [NCIt concept]
- Anti-CLDN18.2/Anti-CD3 Bispecific Antibody ASP2138 [NCIt concept]
- Anti-CLDN18.2/Anti-PD-L1 CAR-T Cells [NCIt concept]
- Anti-CLDN18.2/CD47 Bispecific Antibody AK132 [NCIt concept]
- Anti-Claudin 18.2 Antibody-drug Conjugate BL-M05D1 [NCIt concept]
- Anti-Claudin 18.2 Antibody-drug Conjugate EO-3021 [NCIt concept]
- Anti-Claudin 18.2 Antibody-drug Conjugate JS107 [NCIt concept]
- Anti-Claudin 18.2 Antibody-drug Conjugate SKB315 [NCIt concept]
- Anti-Claudin 18.2 Antibody-drug Conjugate SOT102 [NCIt concept]
- Anti-Claudin-18.2 Monoclonal Antibody NBL-015 [NCIt concept]
- Anti-Claudin-18.2 Monoclonal Antibody SPX-101 [NCIt concept]
- Anti-Claudin18.2 Antibody-drug Conjugate IBI343 [NCIt concept]
- Anti-Claudin18.2 CAR T Cells IBI345 [NCIt concept]
- Anti-Claudin18.2 CAR T Cells LCAR-C18S [NCIt concept]
- Anti-Claudin18.2 CAR-T Cells IM92 [NCIt concept]
- Anti-Claudin18.2 Monoclonal Antibody TORL-2-307-MAB [NCIt concept]
- Anti-Claudin18.2/Anti-4-1BB Bispecific Antibody PM1032 [NCIt concept]
- Anti-Claudin18.2/Anti-CD3 Bispecific Antibody AZD5863 [NCIt concept]
- Anti-Claudin18.2/Anti-CD3 Bispecific Antibody QLS31905 [NCIt concept]
- Anti-Claudin18.2/MMAE Antibody-drug Conjugate TORL-2-307-ADC [NCIt concept]
- Anti-PD-L1/Claudin18.2 Bispecific Antibody Q-1802 [NCIt concept]
- Anti-claudin 18.2 Antibody-drug Conjugate CPO102 [NCIt concept]
- Anti-claudin 18.2 Monoclonal Antibody M108 [NCIt concept]
- Anti-claudin 18.2 Monoclonal Antibody MIL93 [NCIt concept]
- Anti-claudin18.2 Monoclonal Antibody AB011 [NCIt concept]
- Autologous Anti-CLDN18.2 TAC T-cells TAC01-CLDN18.2 [NCIt concept]
- Autologous Anti-Claudin18.2 CAR T-cells LB1908 [NCIt concept]
- Autologous Anti-NKG2DL/Anti-CLDN18.2 Bispecific CAR-T Cells KD-496 [NCIt concept]
- Ciletatug Vedotin [NCIt concept]
- Garetatug Rezetecan [NCIt concept]
- Givastomig [NCIt concept]
- Gresonitamab [NCIt concept]
- Iodine I 124 18B10(10L) [NCIt concept]
- Omectatug [NCIt concept]
- Osemitamab [NCIt concept]
- Satricabtagene Autoleucel [NCIt concept]
- Sonesitatug Vedotin [NCIt concept]
- Spevatamig [NCIt concept]
- Tecotabart [NCIt concept]
- Tecotabart Vedotin [NCIt concept]
- Zolbetuximab [NCIt concept]
- mRNA-encoded Anti-Claudin18.2 Monoclonal Antibody BNT141 [NCIt concept]

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