Preferred Label : Sonesitatug Vedotin;
NCIt synonyms : Anti-CLDN18.2 ADC CMG901; Anti-Claudin18.2 ADC CMG901; Anti-Claudin18.2 ADC AZD0901;
NCIt definition : An antibody-drug conjugate (ADC) composed of sonesitatug, a monoclonal antibody directed
against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18),
conjugated, via a cleavable linker, to the microtubule-disrupting cytotoxic agent
monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration,
sonesitatug vedotin specifically targets and binds to CLDN18.2 expressed on tumor
cells. Upon internalization and the release of MMAE, MMAE targets and binds to tubulin,
and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest
and apoptosis in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein
and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells.
Its expression in healthy tissues is strictly confined to short-lived differentiated
epithelial cells of the gastric mucosa.;
UNII : 96ZG83EF42;
CAS number : 2813237-93-1;
Molecule name : CM-G901; CM G901; AZD 0901; AZD-0901;
NCI Metathesaurus CUI : CL1663033;
Origin ID : C180413;
UMLS CUI : C5556351;
Semantic type(s)
- concept_is_in_subset
- has_target
