Preferred Label : Anti-Claudin18.2 ADC AZD0901;
NCIt synonyms : Anti-CLDN18.2 ADC CMG901; Anti-Claudin18.2 ADC CMG901;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18)
conjugated via a cleavable linker, to the microtubule-disrupting cytotoxic agent monomethyl
auristatin E (MMAE), with potential antineoplastic activity. Upon administration,
anti-CLDN18.2 ADC AZD0901 specifically targets and binds to CLDN18.2 expressed on
tumor cells. Upon internalization and the release of MMAE, MMAE targets and binds
to tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell
cycle arrest and apoptosis in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction
protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor
cells. Its expression in healthy tissues is strictly confined to short-lived differentiated
epithelial cells of the gastric mucosa.;
Molecule name : CM-G901; CM G901; AZD 0901; AZD-0901;
NCI Metathesaurus CUI : CL1663033;
Origin ID : C180413;
UMLS CUI : C5556351;
Semantic type(s)
- concept_is_in_subset
- has_target
