Preferred Label : Anti-Claudin18.2/Anti-4-1BB Bispecific Antibody PM1032;
NCIt synonyms : Anti-CLDN18.2/Anti-4-1BB Bispecific Antibody PM1032; Anti-CLDN18.2/4-1BB Bispecific Antibody PM1032; CLDN18.2 x 4-1BB Bispecific Antibody PM1032; CLDN18.2/4-1BB Bispecific Antibody PM1032;
NCIt definition : A bispecific antibody directed against the tumor-associated antigen (TAA) Claudin18.2
(CLDN18.2; A2 isoform of claudin-18) and 4-1BB (CD137; tumor necrosis factor receptor
superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic
activities. Upon administration, anti-CLDN18.2/anti-4-1BB bispecific antibody PM1032
simultaneously targets and binds to CLDN18.2 expressed on tumor cells and 4-1BB expressed
on a variety of leukocyte subsets including activated T-lymphocytes. Upon CLDN18.2
binding and CLDN18.2-mediated crosslinking of 4-1BB, the 4-1BB activation signal is
induced and PM1032 acts as a conditional 4-1BB agonist in the tumor microenvironment
(TME), resulting in T-cell co-stimulation and T-lymphocyte-mediated anti-tumor activity.
CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is
expressed on a variety of tumor cells. Its expression in healthy tissues is strictly
confined to short-lived differentiated epithelial cells of the gastric mucosa. 4-1BB,
a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible
costimulatory receptor that plays a key role in T-cell proliferation, survival and
cytolytic activity.;
Molecule name : PM-1032; PM 1032;
Origin ID : C200798;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
