Preferred Label : Anti-Claudin18.2 Antibody-drug Conjugate IBI343;
NCIt synonyms : Anti-CLDN18.2 ADC IBI343; ADC IBI343;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18)
conjugated to an as of yet undisclosed cytotoxic agent, with potential antineoplastic
activity. Upon administration, anti-CLDN18.2 ADC IBI343 specifically targets and binds
to CLDN18.2 expressed on tumor cells. Upon internalization, the cytotoxic agent induces
apoptosis in CLDN18.2-expressing tumor cells through an as of yet unidentified mechanism
of action (MoA). CLDN18.2, a tight junction protein and stomach-specific isoform of
claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues
is strictly confined to short-lived differentiated epithelial cells of the gastric
mucosa.;
Molecule name : IBI-343; IBI 343;
NCI Metathesaurus CUI : CL1798637;
Origin ID : C189808;
UMLS CUI : C5706546;
Semantic type(s)
- concept_is_in_subset
- has_target
