Preferred Label : Anti-Claudin 18.2 Antibody-drug Conjugate SHR-A1904;
NCIt synonyms : ADC SHR-A1904; Anti-CLDN18.2 ADC SHR-A1904; Anti-CLDN18.2 Antibody-drug Conjugate SHR-A1904; Anti-Claudin 18.2 ADC SHR-A1904;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) Claudin 18.2 (CLDN18.2; A2 isoform of claudin-18)
conjugated to an as of yet undisclosed cytotoxic agent, with potential antineoplastic
activity. Upon administration of anti-CLDN18.2 ADC SHR-A1904, the anti-CLDN18.2 monoclonal
antibody moiety specifically targets and binds to CLDN18.2 expressed on tumor cells.
Upon binding and internalization, the cytotoxic agent is released and kills the CLDN18.2-expressing
cancer cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18,
is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly
confined to short-lived differentiated epithelial cells of the gastric mucosa.;
Molecule name : SHR A1904; SHR-A1904;
NCI Metathesaurus CUI : CL1663598;
Origin ID : C181025;
UMLS CUI : C5556789;
Semantic type(s)
- concept_is_in_subset
- has_target
