Preferred Label : Ciletatug Vedotin;
NCIt synonyms : ADC RC118; Antibody-drug Conjugate RC118;
NCIt definition : An antibody-drug conjugate (ADC) composed of ciletatug, a humanized immunoglobulin
G1 kappa (IgG1k) monoclonal antibody directed against the tumor-associated antigen
(TAA) Claudin 18.2 (CLDN18.2; A2 isoform of claudin-18), conjugated to the microtubule-disrupting
cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity.
Upon administration, ciletatug vedotin specifically targets and binds to CLDN18.2
expressed on tumor cells. Upon internalization and the release of MMAE, MMAE targets
and binds to tubulin, and inhibits microtubule polymerization. This results in G2/M
phase cell cycle arrest and apoptosis in CLDN18.2-expressing tumor cells. CLDN18.2,
a tight junction protein and stomach-specific isoform of claudin-18, is expressed
on a variety of tumor cells. Its expression in healthy tissues is strictly confined
to short-lived differentiated epithelial cells of the gastric mucosa.;
UNII : 7ER98K4WW9;
CAS number : 2897624-59-6;
Molecule name : RC-118; RC 118;
NCI Metathesaurus CUI : CL1663644;
Origin ID : C180906;
UMLS CUI : C5556707;
Semantic type(s)
- concept_is_in_subset
- has_target
