NCIt definition : An engineered monoclonal antibody directed against the tumor-associated antigen (TAA)
Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating
and antineoplastic activities. Upon administration, anti-CLDN18.2 monoclonal antibody
ZL-1211 specifically targets and binds to CLDN18.2 expressed on tumor cells. The binding
induces antibody-dependent cellular cytotoxicity (ADCC) and activates innate and adaptive
immunity. This kills and inhibits proliferation of CLDN18.2-expressing tumor cells.
CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is
expressed on a variety of tumor cells. Its expression in healthy tissues is strictly
confined to short-lived differentiated epithelial cells of the gastric mucosa.;
Semantic type(s)