Preferred Label : Anti-Claudin18.2 CAR T Cells LCAR-C18S;
NCIt synonyms : Anti-Claudin18.2-CAR-transduced T Lymphocytes LCAR-C18S;
NCIt definition : A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR)
specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform
of claudin-18), with potential immunostimulating and antineoplastic activities. Upon
administration, anti-Claudin18.2 CAR T cells LCAR-C18S specifically recognize and
induce selective toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction
protein, is expressed on a variety of tumor cells, but its expression in healthy tissues
is strictly confined to short-lived differentiated epithelial cells of the gastric
mucosa.;
Molecule name : LCAR-C18S; LCAR C18S;
NCI Metathesaurus CUI : CL1647833;
Origin ID : C178335;
UMLS CUI : C5554960;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
