Preferred Label : Anti-Claudin18.2 CAR-T Cells IM92;
NCIt synonyms : Anti-CLDN18.2 CAR T Cells IM92; Anti-CLDN18.2 CAR-T Cells IM92;
NCIt definition : A preparation of T-lymphocytes engineered to express a chimeric antigen receptor (CAR)
specific for the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform
of claudin-18), with potential immunostimulating and antineoplastic activities. Upon
administration, anti-CLDN18.2 CAR-T cells IM92 specifically recognize and induce selective
toxicity in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein, is
expressed on a variety of tumor cells, but its expression in healthy tissues is strictly
confined to short-lived differentiated epithelial cells of the gastric mucosa.;
Molecule name : IM 92; IM-92;
NCI Metathesaurus CUI : CL1791983;
Origin ID : C187104;
UMLS CUI : C5706348;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
